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Composition and forms of Accutane

Almost everyone who suffers from acne has heard about Accutane. This effective drug is used in the treatment of severe, chronic, large volumes of acne lesions. Treatment should be conducted under the supervision of a physician (for monitoring side effects, prescribing adjuvant drugs and monitoring the effectiveness of the treatment process)

Accutane is a synthetic analog of vitamin A. It is used to treat severe forms of acne, rosacea, and other chronic purulent-inflammatory skin diseases.

Accutane is composed of Isotretinoin and is available in capsules containing 10 or 20 mg of this substance. Another form is the rectal suppository, which is absorbed from the intestine.


Actions of Accutane

  • Isotretinoin inhibits the work of the sebaceous glands, the ducts narrow, their number decreases
  • It has a pronounced keratolytic effect, normalizing the process of cell renewal and eliminating the undesirable process of blockage of the sebaceous glands



  • Pregnancy or pregnancy planning in the near future
  • The use of vitamin "A"
  • Chronic alcoholism
  • Diabetes
  • Renal, hepatic impairment
  • Pancreatitis
  • Hepatitis
  • People prone to depression and other mental disorders should use Accutane with caution, it can provoke or aggravate their course.


Doses of Accutane

It is recommended to start with 0.5 mg/kg of Accutane (Isotretinoin) for four weeks during or immediately after meals; then the dosage is increased to 1 mg/kg for 12-20 weeks. A noticeable therapeutic effect is visible after 1-2 months of use.

Rectally, Accutane (Isotretinoin) is administered at a dosage of 0.5-1 mg/kg at night. The course is from 8 to 12 weeks.


Side effects of Accutane

  • Skin: severe itching, hypersensitivity to the sun, peeling, rash, skin infection
  • Sense organs: burning in the eyes, photophobia, visual impairment, cataract, night blindness
  • Musculoskeletal system: severe joint pain, hyperostosis
  • Nervous system: headaches, weakness, lethargy, depression, suicidal intentions
  • Digestive system: indigestion, dry mouth, gum inflammation and bleeding, hepatitis, colitis
  • Bleeding and dryness of the nasal mucous membrane


Tips for the treatment with Accutane

  • It is necessary to pay attention to the liver function, which is subjected to a stress from this drug. If possible, do a blood test for serum lipids. In the event of hepatomegaly and liver pain, hepatoprotectors restoring its cells are used.
  • It is undesirable to use Accutane in diabetes mellitus, and if necessary, the control of blood glucose levels should be conducted.
  • If there are side effects from the eyes, you should replace the lenses with glasses.
  • If there are symptoms of colitis, signs of visual impairment appeared, it is necessary to cancel the drug.
  • Use of contraceptives during the treatment period is compulsory, and in the event of pregnancy, discontinue the use by medical indications.